Memories linked with strong emotions often become seared in the brain, according to a recent study.
“It makes sense we don’t remember everything,” said Rene Hen, PhD, professor of psychiatry and neuroscience at Columbia University Vagelos College of Physicians and Surgeons.
“We have limited brainpower. We only need to remember what’s important for our future wellbeing,” Hen added.
Fear, in this context, is not just a momentary feeling but a learning experience critical to our survival. When a new situation makes us fearful, the brain records the details in our neurons to help us avoid similar situations in the future, or use appropriate caution.
What’s still a mystery is why these memories, recorded by the brain’s hippocampus, become so strong.
To find out, Hen and Jessica Jimenez, an MD/PhD student at Columbia, placed mice into new, frightening environments and recorded the activity of hippocampal neurons that reach out to the brain’s fear centre (the amygdala).
The neurons’ activity was also recorded a day later when the mice tried to retrieve memories of the experience.
Unsurprisingly, neurons that respond to the frightening environment send that information to the brain’s fear centre.
“What was surprising was that these neurons were synchronized when the mouse later recalled the memory,” Hen said.
“We saw that it’s the synchrony that is critical to establish the fear memory, and the greater the synchrony, the stronger the memory. These are the types of mechanisms that explain why you remember salient events,” Jimenez added.
How and when synchronisation occurs is still unknown, but the answer could reveal the inner workings of the brain that create lifelong memories and lead to new treatments for posttraumatic stress disorder.
“In people with PTSD, many similar events remind them of the original frightening situation, and it’s possible that synchronization of their neurons has become too strong,” Hen said.
“We’re really trying to dig into the mechanisms of how emotional memories form to find better treatments for people with PTSD and memory disorders in general,” Hen noted.
(This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.)
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