BENGALURU: Indian Researchers have recently developed a new-generation non-invasive diagnostic strategy that can help physicians in early and quick diagnosis of
Helicobacter pylori infection
in the stomach through
The strategy called ‘Pyro-Breath’ can detect the bacteria as well as its related complicacies like ulcer and non-ulcerous dyspepsia thus obviating the existing painful endoscopic and biopsy based tests. The research done by Manik Pradhan and his group has been published in the Journal of Breath Research.
They have developed a few prototype breath analysers, one of which has been installed at a hospital in Salt Lake, Kolkata for large-scale clinical trials.
Breath tests are being performed on patients on a regular basis for non-invasive diagnosis of H. pylori bacterial infection as well as gastric disorders. Three startup companies have already shown interest in taking up this technology for commercialization and the transfer of technology (TOT) is currently under process.
Helicobacter pylori infection may lead to the development of peptic ulcer disease and certain types of cancer. The fact that this bacterial infection is often asymptomatic, makes early diagnosis essential to prevent complications.
The ‘Pyro-Breath’ technology, the researchers at SN Bose National Centre for Basic Sciences (SNBNCBS) in Kolkata say, exploits a simple residual gas analyzer (RGA) which scans specific ‘Breath-Print Masses (BPMs)’ in real-time. The SNBNCBS is an autonomous institute under the Department of Science and Technology (DST).
These BPMs are strongly associated with the onset of H. pylori infection and various gastric disorders such as
“From the nature of the various exhaled molecules or their isotopic species (breath-prints), it is possible to non-invasively monitor whether a person has a specific type of gastric disorder or H. pylori bacterial infection or both. As this is a non-invasive and painless method, it would be an attractive and alternative diagnostics method for any person including infants, children, pregnant women and seniors,” the DST said.
This breath test method which can be a game-changer in non-invasive medical diagnosis may also help to follow-up the patients after standard therapies, thus avoiding further painful and invasive endoscopic methods. The group has filed a patent, dated on 21/01/2016 (File No: 201631002214) for this technological innovation.
“Pradhan has established research collaborations with medical scientists to ensure the translation of the new breath analysis technology, for clinical testing. The group has found new ‘Breath-Prints’ and estimated ‘Risk-Factors’ of various gastric disorders for non- invasive diagnosis of these diseases with accuracy better than 96% when compared with ‘gold-standard’ endoscopic tests,” the DST added.