, a genomics and clinical data-driven diagnostics and research company in Bengaluru, on Wednesday said it has conducted a first-ever study on Indian population that validates a novel ‘CAD-PRS’ (coronary artery disease-genome-wide polygenic risk score) to precisely predict the risk of developing a
coronary artery disease
(CAD)/myocardial infarction (MI) using a person’s
The firm collaborated with researchers from Broad Institute of MIT and Harvard; Massachusetts General Hospital, Boston; Narayana Health; Eternal Hospital, Jaipur; Madras Medical Mission, Chennai; KMCH, Coimbatore and a few other institutes to conduct this research capturing the PRS of disease for South Asia populations and its findings are now published in the Journal of the American College of
“Looking at all the available scientific evidence and our study results we are convinced that there exists a good opportunity to combine both clinical and genetic risks (polygenic risk score based) and significantly improve the primary prevention of CAD,” Vedam Ramprasad, CEO, MedGenome Labs, said.
He added that his firm believes that incorporating validated genetic risk scores would help in better stratification of high-risk individuals if implemented at population level. This study, Medgenome said, is based on the principle of Genome-wide PRS which uses a genome-wide analysis of an individual to quantify the risk of developing heart disease.
“It was conducted on the south Asian population in 1,800 confirmed CAD cases and 1,163 control samples from five centres across the country with a median age between 54 and 55 years. The findings of this study have helped develop a CAD PRS that integrates information from millions of sites of common DNA variation into a single metric that can be calculated from birth and validate a scalable polygenic score framework in India,” the firm said in a statement.
The findings lay the scientific and operational foundation for clinical implementation not just for CAD but for other diseases too, the firm said, adding that CAD PRS is a powerful genetic predictor that can be used to identify individuals at increased risk for CAD.
“...It provides a quantified risk score based on one’s genetic makeup and predicts a patient’s risk for having an acute coronary event, such as a heart attack, before symptoms appear. CAD PRS is an important new risk factor to help physicians stratify high-risk patients and better guide treatment decisions and lifestyle interventions,” Sekar Kathiresan, CEO, Verve Therapeutics and professor of medicine, Harvard Medical School, cardiology division, Massachusetts General Hospital, said.
In a statement, Medgenome said that according to a research paper published in the Journal of Genetics, the estimated prevalence of CAD disease in India is about 10.5% of the population which extrapolates to a burden of about 32 million affected individuals.
Further, it points out the incidence of cardiac disorders has increased from 2% to 10.5% of the urban population1 in the past few years and the early age of onset is a new countrywide trend.
“South Asians no matter where they stay – in India or any other country always have higher cases of CAD than Caucasians. Even if our body structure is much leaner, smaller and thus comparatively lower food consumed compared to Caucasians, we still end up with CAD. So, it can be considered that South Asians have some genetic issues causing high CAD cases and hence we need to identify these genetic factors so that we are able to manage the disease in our population,” Dr Ajit Mullasari, director
, Madras Medical Mission, said.